10.2 Introduction to the Lymphatic System

The lymphatic system (see Figures 10.1, 10.2, and 10.3 for an anatomical overview) includes lymphatic capillaries, lymphatic vessels, lymph nodes, and other lymphoid tissues. This system plays a valuable role in fluid balance and filtering pathogens and waste such as cellular debris. Assessment of the lymphatic system provides important information about the functioning of this system and potential cues that require further action.

The lymphatic system involves the following processes:

  • Fluids and proteins leak from the vascular system into the interstitial space. As previously discussed in the peripheral vascular chapter, much of this fluid is reabsorbed back into the venous system.
  • Some of the fluid and proteins (including waste and pathogens) in the interstitial space are absorbed by the lymphatic capillaries into the lymphatic system, which becomes lymph (i.e., lymphatic fluid that is rich in proteins).
  • The lymph travels along the lymphatic vessels so that fluid and proteins can be returned from the lymphatic system into the bloodstream to ensure sufficient blood volume in the cardiovascular system. The lymph is returned to the bloodstream through the right lymphatic duct and the thoracic duct into the subclavian veins. Attached to the lymphatic vessels are hundreds of lymph nodes throughout the body, which filter the lymph and cleanse it. 
  • Lymph nodes can be found all over the body and are often assessed in the head/neck, axilla, anterior chest, upper arm, and groin areas.

You have already learned about the anatomy and physiology of the lymphatic system; here is a quick overview of how it works [YouTube video]. An additional resource is this crash course on the lymphatic system [YouTube video].

Clinical Tip

The lymphatic system is rarely assessed in isolation because it is closely linked to many other systems including the cardiovascular system, peripheral vascular system, respiratory system, immune system, gastrointestinal system, and musculoskeletal system.
Components of the lymphatic system. More information in the links.
Figure 10.1: Overview of lymphatic system.
The location of the right lymphatic duct and the thoracic duct on the left side.
Figure 10.2: Lymphatic ducts.
How the lymphatic capillaries connect in the interstitial spaces. More information in the links.
Figure 10.3: Lymphatic capillaries.

Attribution for all three images: Gordon Betts, J., Young, K.A., Wise, J.A., Johnson, E., Poe, B., Kruse, D.H., Korol, O., Johnson, J.E., Womble, M., & DeSaix, P. (2013). The Lymphatic and Immune System. In Anatomy and Physiology. OpenStax. Creative Commons Attribution License v4.0. Book URL: https://openstax.org/books/anatomy-and-physiology/pages/1-introduction

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